Stefan Knapp
Prof Stefan Knapp studied Chemistry at the University of Marburg (Germany) and at the University of Illinois (USA). He did his PhD in protein crystallography at the Karolinska Institute in Stockholm. In 1999, he joined the Pharmacia (Nerviano Italy) and left the company in 2004 to set up a research group at the Structural Genomics Consortium at Oxford University. From 2008 to 2015 he was a Professor of Structural Biology at Oxford University (UK) and from 2012 to 2015 the director for Chemical Biology at the Target Discovery Institute at Oxford University. He joined Frankfurt University in 2015 as a Professor of Pharmaceutical Chemistry. Since 2017 he is also the CSO of the SGC (Structure Genomics Consortium) node at the Goethe-University Frankfurt. His research interests are unravelling molecular/structural mechanisms of kinase regulation and using high resolution structures, the design of selective kinase inhibitors and inhibitors of protein interactions domains such as bromodomains that are principal readers of the epigenetic acetylation code and E3 ubiquiting ligases.
Yulin Lu
Jeff McKenna
Walker Graham
Nathaniel
Greg Hollingworth
Max Johansen
C. Vivek Lal
Karen Miller
Initial introduction to molecular glues during tenure at Celgene from 2010-2015 where she was a key member on the IMiD “mechanism of action” discovery team. Work here directly contributed to the clinical development of pomalidomide and downstream mechanistic discovery of IMiDs including in-house identification of Ikaros, Aiolos, and GSPT1 as neosubstrates of various IMiD molecules. Subsequently, left Celgene to obtain her PhD from The Scripps Research Institute under the tutelage of Dr. Michael McHeyzer-Williams, focusing on adaptive immunity through germinal center formation and evolution. Following completion of her degree in 2021, she returned to the TPD space, moving to Biotheryx where she is currently the biology lead for both the BTX-1188 and Neosubstrate Discovery projects.